Description
Product Characteristics: Amyloid fibril protein AA, Amyloid fibrils, PIG4, Serum amyloid A protein (SAA), Serum amyloid A1 isoform 1 (SAA1), Serum amyloid A1 isoform 2 (SAA2), Tumor protein p53 inducible protein 4 (TP53I4),Serum Amyloid A
Cellular localisation: Cytoplasmic & extracellular (secreted)
Target Information: This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]